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Haematological disorders of Polycythaemia rubra vera or Thrombocytosis (excessive red cells or platelets)
Systemic pruritus has been linked to cholestasis, thyroid disease, polycythaemia rubra vera, uraemia, Hodgkins disease, HIV and other immunodeficiency diseases.
Clonal Disorders of the Bone Marrow associated with eosinophilia: Acute and chronic eosinophilic leukaemia, chronic myeloid leukaemia, polycythaemia rubra vera, essential thrombocythaemia, acute myeloid leukaemia.
Elliott MA, Tefferi A: Thrombosis and haemorrhage in polycythaemia vera and essential thrombocythaemia.
Squizzato A, Romualdi E, Middeldorp S: Antiplatelet drugs for polycythaemia vera and essential thrombocythaemia.
Sacchi S: The role of alpha-interferon in essential thrombocythaemia, polycythaemia vera and myelofibrosis with myeloid metaplasia (MMM): a concise update.
James C, Ugo V, Le Couédic JP, et al.: A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera.
In May 2007, Susan Hoover, Latimer's wife, announced through the Camel Productions website and newsletter that Latimer suffered from a progressive blood disorder polycythaemia vera since 1992, which had later progressed to myelofibrosis.
It also has activity against cells expressing JAK2(V617F), a mutated form of the janus kinase 2 (JAK2) enzyme that is implicated in the pathophysiology of many myeloproliferative diseases, including polycythaemia vera.
Givinostat is in numerous phase II clinical trials (including for relapsed leukemias and myelomas), and has been granted orphan drug designation in the European Union for the treatment of systemic juvenile idiopathic arthritis and polycythaemia vera.