plasma renin activity

Plasma renin activity was low and changed with treatment (table).

Mineralocorticoid is only added in cases where the plasma renin activity is high.

This is measured by the plasma renin activity (PRA).

The screening test of choice for diagnosis is the plasma aldosterone:plasma renin activity ratio.

Plasma renin activity.

Experience in Kenyan hypertension clinics confirms reports that black hypertensive patients have lower plasma renin activities than white patients.

In this regard, increased plasma renin activity and decreased renal prostaglandin production have been reported in patients with acute liver failure.

Indomethacin also reduces plasma renin activity and aldosterone levels, and increases sodium and potassium retention.

Findings in Conn syndrome include low serum potassium, low plasma renin activity, and high serum aldosterone.

As a result of losartan dosing, plasma renin activity increases due to removal of the angiotensin II feedback.

Like hyperaldosteronism, it produces hypertension associated with low plasma renin activity, and metabolic alkalosis associated with hypokalemia.

Three independent risk factors for the development of HRS in cirrhotics have been identified: liver size, plasma renin activity, and serum sodium concentration.

Plasma renin activity was estimated (after standardised sampling) by radioimmunoassay of angiotensin I generated by incubating plasma for four hours.

Aldosterone-to-renin ratio (ARR) is the mass concentration of aldosterone divided by the plasma renin activity in blood plasma.

Hence we routinely utilize plasma renin activity measurements in screening hypertensive subjects prior to providing any dietary advice to limit salt and/ or to increase calcium intake.

At the start of the trial and at the end of each stage patients were weighed and full biochemical blood screens, including plasma renin activity, were carried out.

The reduction in intravascular volume induces an elevation in plasma renin activity and aldosterone secretion, further contributing to the potassium loss associated with thiazide diuretic therapy.

A measurement of aldosterone in blood may be termed a plasma aldosterone concentration (PAC), which may be compared to plasma renin activity (PRA) as an aldosterone-to-renin ratio.

Although studies have revealed that only a small subgroup of such diabetics have reduced plasma renin, in those with nephropathy both plasma renin activity and plasma aldosterone tend to be decreased (Christlieb, 1978).

This may be important as weight loss with accompanying reduction of blood pressure in obese non-diabetic hypertensives has been shown to be accompanied by reduced levels of plasma renin activity and aldosterone (Tuck et al, 1981).

It has been observed that sodium restriction tends to be more beneficial in hypertensives who have low plasma renin activity and in whom the aldosterone response to lowering dietary sodium is poor (Vaughan et al, 1973).

The following table gives the lower limit (2.5th percentile) and upper limit (97.5th percentile) for plasma renin activity by mass and MCU, with different values owing to various factors of variability of reference ranges:

A reduction in Ang II levels or blockade of angiotensin receptors will suppress the feedback loop and lead to increased plasma renin concentrations (PRC) and plasma renin activity (PRA).

Liddle's syndrome, also called Liddle syndrome and pseudoaldosteronism, is an autosomal dominant disorder characterized by early, and frequently severe, hypertension associated with low plasma renin activity, metabolic alkalosis due to hypokalemia, and normal to low levels of aldosterone.

Conn syndrome (mineralcorticoid excess) is marked by high blood pressure which can result in headache and hypokalemia (low serum potassium, which can in turn produce muscle weakness, confusion, and palpitations) low plasma renin activity, and high serum aldosterone.