piritramide

Piritramide tends to cause less respiratory depression than morphine and can take a while to have full effect especially if taken by mouth.

Other somewhat more distant relatives include alphaprodine (Nisentil) and piritramide (Dipidolor).

Before each session the patient received 40 mg promethacine by mouth and 15 mg piritramide intravenously for analgesia.

Piritramide's most common trade name is Dipidolor and it is used most heavily in the Netherlands, Denmark, and Germany.

Kay B, A clinical investigation of piritramide in the treatment of postoperative pain, Br J Anaesth.

In addition to PCA, piritramide is most often used in post-operative situations and emergency departments; some of its properties would seem to lend it well to chronic pain control as well.

Research into the usefulness of piritramide, extended-release hydromorphone including polymer implants lasting up to 90 days, dihydroetorphine and some other drugs for this purpose is in various stages in a number of countries at present.

Difenoxin (Motofen, R-15403) is a 4-phenylpiperidine derivative that is related to the opioid analgesic drug pethidine (meperidine) and more distantly related to alphaprodine and piritramide, and it is an active metabolite of the anti-diarrhoea drug diphenoxylate.

From 1931 to 1961, most of the families of synthetic opioids had been developed, including drugs in whatever way related to methadone, pethidine, morphinans and dextromoramide and related drugs; research on fentanyls and piritramide was also nearing fruition at that point.