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There is concern that creatine might cause a skin condition called pigmented purpuric dermatosis in some people.
Pigmented purpuric dermatosis are distinguished from other purpura by size (0.3-1 cm) and are most often seen in the lower extremities.
It may occur in the lungs as pulmonary capillaritis, or in the skin as pigmented purpuric dermatosis.
There may be overlapping characteristics among pigmented purpuric dermatosis and between their signs and those of other purpuric eruptions.
Chorney JA, Cohen J. Pigmented purpuric dermatosis associated with creatine supplementation (letter).
Pigmented purpuric dermatosis (also known as "progressive pigmentary dermatosis," "purpura pigmentosa chronica," "pigmentary purpuric eruptions," or "progressive pigmenting purpura") refers to one of the three major classes of skin conditions characterized by purpuric skin eruptions.