piebaldism

Outside of pigmentation, piebaldism is an otherwise benign condition.

Humans have a similar genetic disorder, called piebaldism, that results in white spots on a person's forehead and belly.

Conditions associated with abnormalities in the migration of melanoblasts are known collectively as piebaldism.

Although piebaldism may visually appear to be partial albinism, it is a fundamentally different condition.

Piebaldism and amelanism are distinct conditions.

Migration of 3 Types of Cells Similar genetic mutations are now thought to cause a human disorder called piebaldism.

The precise mechanisms that create spotting are not all fully understood, but those that are known often have human parallels, such as piebaldism.

In humans, a skin condition called piebaldism is caused by more than a dozen distinct mutations in the KIT gene.

Piebaldism in humans is characterized by a white forelock, and pigmentless patches of skin on the forehead, brow, face, ventral trunk and extremities.

Dominant white: A family of sabino-like white spotting patterns, all dominant white coats are dominantly inherited, analogous to human piebaldism.

In other animals, patches of unpigmented skin, hair, or eyes due to the lack of pigment cells (melanocytes) are called piebaldism, not albinism nor partial albinism.

Mutations in the human KIT gene have been identified as a cause of Piebaldism, a rare autosomal dominant disorder of melanogenesis characterized by patchy absence of pigmentation of the skin and overlying hair.

Activating mutations in this gene are associated with gastrointestinal stromal tumors, testicular seminoma, mast cell disease, melanoma, acute myeloid leukemia, while inactivating mutations are associated with the genetic defect piebaldism.