phospholipase B

Phospholipase B domain containing 1 is a protein that in humans is encoded by the PLBD1 gene.

Phospholipase B - cleaves both SN-1 and SN-2 acyl chains; this enzyme is also known as a lysophospholipase.

Enzymes having phospholipase B activity hydrolyze both the sn-1 and sn-2 positions, so they produce both 1-lysoPC and 2-lysoPC.

An enzyme that displays both phospholipase A1 and phospholipase A2 activities is called a Phospholipase B (see main article on phospholipases).

Additional types of phospholipases include phospholipase A1, phospholipase B, phospholipase C, and phospholipase D.

Phospholipase B enzymes catalyse the release of fatty acids from lysophsopholipids and are capable in vitro of hydrolyzing all phospholipids extractable from yeast cells.

Neuropathy target esterase is an enzyme with phospholipase B activity: It sequentially hydrolyses both fatty acids from the major membrane lipid phosphatidylcholine, which generates water-soluble glycerophosphocholine.

Phospholipase B is an enzyme with a combination of both PLA1 and PLA2 activities; that is, it can cleave acyl chains from both the sn-1 and sn-2 positions of a phospholipid.

Other names in common use include lecithinase B, lysolecithinase, phospholipase B, lysophosphatidase, lecitholipase, phosphatidase B, lysophosphatidylcholine hydrolase, lysophospholipase A1, lysophopholipase L2, lysophospholipase transacylase, neuropathy target esterase, NTE, NTE-LysoPLA, and NTE-lysophospholipase.