phagocytic vacuole

Upon phagocytosis by a macrophage, the Leishmania parasite finds itself in a phagocytic vacuole.

Under normal circumstances, this phagocytic vacuole would develop into a lysosome and its contents would be digested.

Others avoid lysosomes by leaving the phagocytic vacuole, to reach the cytosolic matrix where their development is unhindered.

IRGs confer resistance from vacuolar pathogens by localizing to and disrupting the phagocytic vacuole during infection.

Intact M. haemofelis organisms have been observed in the phagocytic vacuoles of splenic and pulmonary macrophages, suggesting that these cells may serve as reservoirs.

Neutrophils in particular are known for containing azurophils loaded with a wide variety of anti-microbial defensins that fuse with phagocytic vacuoles.

Listeria monocytogenes, some species of Rickettsia, Shigella flexneri and other intracellular germs escape from phagocytic vacuoles by coating themselves with a capsule of actin filaments.

Mutant bacteria with a transposon insertion in prfA (DP-L1075) [ 33] adhere to the host-cell surface, and induce their own uptake into a phagocytic vacuole, presumably through low-level expression of the internalins, but cannot escape from the phagocytic vacuole into the cytoplasm.