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This is why acroosteolysis and periosteal bone formation can be explained by the action of PGE.
The bone collar is a cuff of periosteal bone that forms around the diaphysis of the hyaline cartilage model in developing long bones.
Since PGE is likely to be involved in periosteal bone formation and acroosteolysis, this is why these drugs can alleviate the polyarthritis associated with PDP.