periarticular

For local periarticular injection, mice were anesthetized with inhalation of 2.5% isoflurane gas.

Lameness is often observed in periarticular HS.

In contrast, the present results demonstrate that local IL-4 delivery was able partially to reverse progression of established disease after local periarticular injection.

The soft tissues are also involved with the swelling of the periarticular tissues, especially heel pads and the finger pads.

Periarticular HS has a distinctive appearance: it occurs as multiple tan nodules located in the subsynovium.

Other features include periarticular osteopenia, squaring of metacarpals and phalanges and bilateral joint effusions.

This chronic disease not only affects the articular cartilage but the subchondral bone, the synovium and periarticular tissues are other candidates.

Taken together, these results suggest that local periarticular injection of Ad-mIL-4 resulted in a therapeutic effect in both injected and noninjected joints.

In the present study we examined the ability of local periarticular gene transfer of IL-4 to treat established murine CIA.

Tumoral calcinosis is a rare condition in which there is calcium deposition in the soft tissue in periarticular location i.e. around joints.

In contrast, periarticular injection of Ad-mIL-10 did not affect the level of expression of endogenous levels of IL-4 (Fig.

P. Barbagli, R. Bollettin: Therapy of articular and periarticular pain with local anesthetics (neural therapy of Huneke).

In contrast, periarticular injection of Ad-mIL-4 was able to reverse pathology in established disease not only in the treated hind paws, but also in the untreated front paws.

The ability of Ad-mIL-4 to treat established CIA was evaluated by local periarticular and systemic intravenous injection of Ad-mIL-4 into mice at various times after disease onset.

Some health care providers may use these terms to refer to fibromyalgia: fibromyositis, fibrositis, periarticular fibrositis, muscular rheumatism, chronic muscle pain syndrome, musculoskeletal pain syndrome, or tension myalgia.

He first described the knee joint problem Baker's cyst which is named after him, as are Baker's cannula, a flexible tracheal cannula and Baker's disease a defect of the periarticular ligaments.

Although many genes have been effective in treating murine CIA if they are administered before disease onset, local periarticular gene transfer has not been highly effective in halting the progression of established disease.

Periarticular delivery of murine or viral IL-10 by gene transfer resulted in the inhibition of CIA in mouse models [ 10, 26] if delivered before or at the time of disease onset.

We have demonstrated previously that periarticular injection of adenovirus-mediated gene transfer of v-IL-10 into the hind paws of mice with early-stage arthritis was able to confer a therapeutic effect in the untreated front paws.

Milwaukee Shoulder Syndrome (apatite-associated destructive arthritis) is a rheumatological condition similar to Calcium pyrophosphate dihydrate deposition disease (CPPD), and is the result of periarticular or intraarticular deposition of hydroxyapatite crystals.

In the case of periarticular HS which occurs in the subsynovial tissues of the extremities, amputation of the affected limb is enforced by the inoperable nature of the primary lesion which ensnares structures vital to limb function.

Other possible mechanisms for the development of ganglion cysts include repeated mechanical stress, facet arthrosis, myxoid degeneration of periarticular fibrous tissues and liquefaction with chronic damage, increased production of hyaluronic acid by fibroblasts, and a proliferation of mesenchymal cells.

In order to examine the therapeutic effects of IL-4 gene transfer in a murine model of arthritis, increasing doses of an Ad-mIL-4 recombinant virus were administered by periarticular injection into the hind ankle joints of mice with established disease 4 days after lipopolysaccharide injection.

Smith, T. J., Fitzpatrick, N., Evans, R. B. and Pead, M. J. (2009), Measurement of Ulnar Subtrochlear Sclerosis Using a Percentage Scale in Labrador Retrievers with Minimal Radiographic Signs of Periarticular Osteophytosis.