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Chiral auxiliaries derived from readily available chiral alcohols (such as pantolactone) may be used for diastereoselective cyclopropanations with diazo esters.
In addition, several aliphatic, monocarboxylic acid salts, including hydrolysis products from pantolactone and butyrolactone, were also active in one or both of these mutants, especially pantoate and other hydroxy acid salts in the ruv bacterium.
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