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It is important to keep in mind that these two mechanisms of outbreeding depression can be operating at the same time.
This leads to a low risk of outbreeding depression.
In contrast, outbreeding depression can be relatively weak in the first generation.
This is a form of outbreeding depression.
Second, not all hybrids exhibit heterosis (see outbreeding depression).
Finally dispersal can also lead to outbreeding depression if an individual is better adapted to its natal environment than the one it ends up in.
This vortex can result from biological invasion, resulting in large scale hybridization and outbreeding depression.
Researchers have also identified potential interbreeding as threatening the Maui's with hybrid breakdown and outbreeding depression.
A second cause outbreeding depression may be the breakdown of biochemical or physiological compatibilities between genes in the different breeding populations.
Crossing the hybrids will give unpredictable outcomes and outbreeding depression will remain or worsen so that is not common practice.
It is maintained that local seed is best adapted to local conditions (local adaptation) and outbreeding depression will be avoided.
However, intermixing two different populations may give rise to unfit polygenic traits in outbreeding depression, yielding offspring which lack the genetic adaptations to specific environmental conditions.
Whereas the second two (F and A) deal with genetic factors such as inbreeding depression and outbreeding depression, genetic drift etc.
However, it is critical to understand that reduced inbreeding depression in first generation hybrids can, in some circumstances, be strong enough to more than make up for outbreeding depression.
Measuring the impact of inbreeding and outbreeding depression, and the relationship between heterozygosity and measures of fitness (see Fisher's fundamental theorem of natural selection).
For example, the outcrossing nematode Caenorhabditis remanei has been demonstrated to suffer severely from inbreeding depression, unlike its hermaphroditic relative C. elegans, which experiences outbreeding depression.
There can be problems if birds of unknown pedigree are released into the wild, as the viability of such hybrids and their offspring is often reduced (see Haldane's Rule and outbreeding depression).
A concept in biology, outbreeding depression refers to cases when offspring from crosses between individuals from different populations have lower fitness than progeny from crosses between individuals from the same population.
Although hybridisation has not been detected elsewhere, it could pose a threat to the wolf population's genetic integrity, resulting in outbreeding depression or a reduction in fitness, though this does not appear to have taken place.
But outside the context of ruthless selective pressure, outbreeding depression will increase in power through the further generations as co-adapted gene complexes are broken apart without the forging of new co-adapted gene complexes to take their place.
The sterility and other fitness-reducing effects often seen in interspecific hybrids (such as mules) can be considered an extreme case of this type of outbreeding depression, involving not only different alleles of the same gene (as in distinct populations of a single species) but even different orthologous genes.