otodental syndrome
otodental dysplasia

The cause of otodental syndrome is considered to be genetic.

Currently there are no open research studies for otodental syndrome.

There is currently no specified treatment for individuals suffering from otodental syndrome.

Symptoms of otodental syndrome can and usually appear in early development and progress with age.

The functional prognosis is mostly good with those that suffer from otodental syndrome.

This is the alleged cause of the physical abnormalities and symptoms associated with otodental syndrome.

Individuals diagnosed with otodental syndrome can be of any age; age is not a relevant factor.

Also, haploinsufficiency in the FGF3 gene is thought to cause otodental syndrome.

A formal diagnosis of no premolar growth can be done by age 6 in order to check for signs of otodental syndrome.

Diagnosis of otodental syndrome was established using clinical, histopathological and audiometric methodologies.

Otodental syndrome is a rare condition that is genetically inherited in an autosomal dominant manner.

The most recent research has involved case studies of the affected individuals and/or families, all of which show the specific phenotypic symptoms of otodental syndrome.

Absent premolars - individuals suffering from otodental syndrome will typically lack the ability to develop premolars due to its genetic related affects.

Due to the rarity of otodental syndrome, most symptoms are looked at on an individual basis unless multiple symptoms are all apparent at once.

Haploinsufficiency in the fibroblast growth factor 3 (FGF3) gene (11q13) has been reported in patients with otodental syndrome and is thought to cause the phenotype.

The first known case of otodental syndrome was found in Hungary in a mother and her son by Denes and Csiba in 1969.

Additional tests that can help diagnose otodental syndrome are ear infection tests, hearing tests, oral examination, and eye examinations to check for the specific phenotypic associations.

Although there is no specific biological mechanism for otodental syndrome, what is recognized is that there is a genetic mutation, known as haploinsufficiency, that occurs in the fibroblast growth factor 3 (FGF3) gene (11q13).

Otodental syndrome, also known as otodental dysplasia, is an exceptionally rare disease that is distinguished by a specific phenotype known as globodontia, that in rare cases can be associated with eye coloboma and high frequency hearing loss.

Otodental syndrome, also known as otodental dysplasia, is an exceptionally rare disease that is distinguished by a specific phenotype known as globodontia, that in rare cases can be associated with eye coloboma and high frequency hearing loss.