orofacial cleft

Racial and ethnic variations in the prevalence of orofacial clefts in California, 1983-1992.

Clinical diagnosis based on orofacial clefts and lip pits typically occurs shortly after birth.

An increase in orofacial clefts was not demonstrated however and it was concluded that benzodiazepines are not major teratogens.

"A Study of Relationships Between Judgments of Speech and Appearance of Patients With Orofacial Clefts".

The frequency of orofacial clefts ranges from 1:1000 to 1:500 births worldwide, and there are more than 400 syndromes that involve cleft lip with or without cleft palate.

Furthermore, approximately 15% of VWS cases with orofacial clefts, in the absence of prominent lip pits, cannot be easily distinguished from non-syndromic forms of orofacial clefting.