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Of the 14 patients who did not have Alzheimer's disease, 12 showed no such changes in the olfactory cells.
"As I said, the olfactory cells need a chemical to trigger them.
In the future, nose drops that stimulate cell growth may arrest the decline of olfactory cells.
Such is the case in olfactory cells.
These olfactory cells bear receptors that unite with odor molecules.
Our nasal epithelia are equipped with a million olfactory cells per every one and a half square inches.
Odoriferous substances, such as essential oils, throw off molecules which are detected by the olfactory cells in the upper part of the nose.
The researchers obtained similar results when they repeated their experiment, this time coating the balance with membranes obtained from human olfactory cells.
They say that the more soluble a substance is in the lipid matrix of olfactory cells, the more intense the smell we perceive.
Similarly, the plasma membrane of olfactory cells seems to have an InsP 3 -sensitive calcium channel.
The olfactory cells of the epithelium are bipolar neurons which congregate to form the olfactory nerve.
They found varying degrees of evidence of the abnormal proteins in the olfactory cells in eight of the nine with Alzheimer's disease.
Viral infections, for example, can destroy the odor-sensitive olfactory cells, and head injuries can disrupt nerve connections to the brain.
Genetically altered all future generations to remove the nerves for both the olfactory cells and the VMO."
In the olfactory system, odorant molecules in the mucus bind to G-protein receptors on olfactory cells.
Prolonged exposure to toxic substances, including air pollutants, industrial chemicals, tobacco smoke and certain drugs, can diminish and sometimes permanently destroy the sensitivity of olfactory cells.
Though human noses have an impressive 5 million olfactory cells with which to smell, sheepdogs have 220 million, enabling them to smell 44 times better than man.
When you chew or swallow, odor-bearing molecules from the food travel through the back of the mouth and into the upper nasal cavity, where they stimulate the olfactory cells.
Resting on the basal lamina of the olfactory epithelium, basal cells are stem cells capable of division and differentiation into either supporting or olfactory cells.
Analogous to neural glial cells, the supporting cells (a.k.a. Sustentacular cells) of the olfactory epithelium function as metabolic and physical support for the olfactory cells.
Scientists believe that molecules of an odorous substance meeting the membranes of specialised olfactory cells somehow trigger electrical signals to the brain, and this is the foundation of smell perception.
The molecules start a process by which olfactory cells send messages to the olfactory bulb, a structure in the front of the brain that is a clearinghouse for the sense of smell.
Both electrophysiological and biochemical evidence suggests that InsP 3 acts on a calcium channel of M r 107K which is located in the plasma membrane of catfish olfactory cells.
Taste buds, the cells of the carotid and aortic bodies, the olfactory cells of the nose. . . we couldn't do much with those, so naturally that was where we concentrated our efforts."
Because the sensory processes ('hairs') are in direct contact with the source of smell, and because the olfactory cells connect directly with the brain, the sense of smell has a powerful and immediate effect.