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Odorant-binding proteins interact with these cilia stimulating the receptors.
Odorant-binding protein 2a is a protein that in humans is encoded by the OBP2A gene.
The apical poles of these neurons are covered with non-motile cilia, with the plasma membrane containing odorant-binding proteins acting as olfactory receptors.
The aqueous solubility of hydrophobic odorants is greatly enhanced via odorant-binding proteins, which exist in the extracellular fluid surrounding the odorant receptors.
Odorant-binding proteins are abundant small soluble proteins secreted in the nasal mucus of many animal species and in the sensillar lymph of chemosensory sensilla of insects.
Odorants penetrate into the cuticle pores of chemosensory sensilla and get in contact with insect Odorant-binding proteins (OBPs) or Chemosensory proteins (CSPs), before activating the sensory neurons.
The product of a gene expressed in the olfactory system of Drosophila melanogaster (Fruit fly), OS-D, shares features common to vertebrate odorant-binding proteins, but has a primary structure unlike odorant-binding proteins.