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This is followed by a rapid reaction with the nucleophile.
In the reaction product the nucleophile has replaced the leaving group.
This strong nucleophile can then be used as such with other electrophiles.
For the reaction to be successful, the nucleophile must have a pKa less than 15.
In humans, the nucleophile of the hydrolysis reaction is Glu-268.
It is a powerful nucleophile that can be used to prepare methylthioethers.
One acts as a nucleophile and the other as an acid/base.
This observation is most often noted when the base is also a nucleophile.
LDA can, however, act as a nucleophile under certain conditions.
The nucleophile will attack the mercurinium ion at this time.
The nucleophile can be a phenol, a phthalimide or simply water.
This unusual salt has several uses in organic chemistry as a base and nucleophile.
S2 occurs where the central carbon atom is easily accessible to the nucleophile.
Instead, Glu-537 is the actual nucleophile, binding to a galactosyl intermediate.
The nucleophile can be carbon, nitrogen or oxygen based.
A base is required for in-situ generation of the nucleophile from a precursor.
This occurs even if the equivalents of nucleophile are closely controlled.
It functions as a base, a ligand, a nucleophile and a catalyst.
It is also a nucleophile for the production of methyl ethers.
This makes this atom the primary target for the nucleophile.
When the proton is taken away by a base, the thiol can become a nucleophile.
Usually one of the groups is a nucleophile and the other is a hydrogen atom.
First, there is a series of deprotonations that make the serine a better nucleophile.
When a nucleophile adds to a conjugated carbonyl system, the result is a 1,4-addition.
The electrophiles are attacked by the most electron-populated part of one nucleophile.