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This may be due to a nondisjunction in the father.
This genetic condition almost always results from nondisjunction during meiosis.
When the separation is not normal, it is called 'nondisjunction'.
The following diagram shows the two possible types of nondisjunction in meiosis:
Mitotic nondisjunction after conception would lead to mosaicism, and is discussed later.
This is due to a mis-segregation (nondisjunction) during gametogenesis.
I stare at the 20th pair, which in our case had the nondisjunction, the pair that did us in.
An error in cell division called nondisjunction can result in reproductive cells with additional chromosomes.
Mechanisms of nondisjunction in human spermatogenesis.
This is thought to be caused by nondisjunction in chromosomes but the mechanism by which it occurs is not well understood.
Down syndrome, Turner Syndrome, and a number of other diseases result from nondisjunction of entire chromosomes.
In some cases, the addition of an extra Y-chromosome results from nondisjunction during cell division during a post-zygotic mitosis in early embryonic development.
However, with nondisjunction, a gamete is produced with an extra copy of chromosome 21 (the gamete has 24 chromosomes).
Numerical errors can arise at either of the two meiotic divisions and cause the failure of a chromosome to segregate into the daughter cells (nondisjunction).
This makes sense, since these cancers often fail to inactivate the X chromosome, and X chromosome nondisjunction leads to more male worms.
Such Down syndrome trisomies are indistinguishable from Down syndrome trisomies created through meiotic nondisjunction.
Because of the unusual cruciform pairing configuration in translocation heterozygotes, nondisjunction of homologous centromeres occurs at a measurable but low rate.
In these cases (all from mothers), the ovaries were trisomy 21, leading to a secondary nondisjunction during gametogenesis and a gamete with an extra chromosome 21.
The extra X chromosome results from either meiotic nondisjunction, in which a chromosome pair fails to separate during meiosis, or from anaphase lag.
First, Rec12 may be required for an "MI nondisjunction checkpoint" that delays meiotic cells in which proper MI disjunction has failed to occur.
Full trisomy 13 is caused by nondisjunction of chromosomes during meiosis (the mosaic form is caused by nondisjunction during mitosis).
In the absence of Rec12 protein and crossovers, a backup distributive (achiasmatic) segregation system operates successfully on up to half of the chromosomes that would otherwise undergo MI nondisjunction.