nitrosative stress

It appears to be involved in bacterial nitric oxide detoxification and in nitrosative stress.

The combination of elevated nitric oxide in tumours and oxygen radicals produces damaging nitrosating oxidants ('nitrosative stress').

Reactive nitrogen species act together with reactive oxygen species (ROS) to damage cells, causing nitrosative stress.

Key words: fission yeast, nitrosative stress, nutritional stress, nitrogen starvation, Pap1, Pbh1, regulation, Schizosaccharomyces pombe.

This approach demonstrated that flavoHb is indeed enzymatically active within human and murine cells and potently blocks exogenous and endogenous sources of nitrosative stress.

NODs are now known to serve two important physiological functions in diverse life forms: they prevent NO toxicity (otherwise known as "nitrosative stress") and regulate NO signalling.

Deleting the GSNOR gene from both yeast and mice increased the cellular levels of GSNO and nitrosylated proteins, and the yeast cells showed increased susceptibility to nitrosative stress.