nicotine receptor

The idea is to home in on certain types of nicotine receptors in the brain, he said.

C1 A nicotine receptor, a gene, and a clue to schizophrenia.

However, since dopamine-releasing neurons are abundant on nicotine receptors, dopamine is released.

Some have theorized that alcohol lowers the ability of nicotine receptors in the brain to respond to the drug, creating a desire for more cigarettes.

Varenicline, the latest antismoking drug to win FDA approval, works by blocking nicotine receptors in the brain.

Most recently, the F.D.A. approved Chantix, which works by binding to the nicotine receptors in the brain.

Once in the brain, it binds to specific nicotine receptors resulting in the release of neurotransmitters, such as dopamine and norepinephrine.

Nicotine's Future Developing new drugs that selectively target specific subtypes of nicotine receptors is an expensive, albeit potentially lucrative, proposition.

Contrary to the predictions, nicotine receptor alpha7 subunit knockout mice do not show disruptions in PPI.

Varenicline is a nicotinic receptor partial agonist - it stimulates nicotine receptors more weakly than nicotine itself does.

Currently nicotine receptor agonist research and drug designing is aimed for treatment of multiple diseases and disorders of the CNS.

"I know one lab that studies nicotine receptors and all the scientists are smokers, and another lab that studies impulse control and they're all overweight."

Newhouse also heads two studies of nicotinic stimulation in ADHD, using the patch, nicotine blockers, and some novel drugs that activate nicotine receptors.

Cahill K, Stead LF, Lancaster T: Nicotine receptor partial agonists for smoking cessation.

Several pharmaceutical companies are working on drugs that target nicotine receptors in the brain, in the hope that they can replicate the cognitive uptick that smokers get from cigarettes.

"If you can dissect out the important players with respect to which nicotine receptors are tuning [a] particular set of synapses, then that provides another way to potentially target the therapeutics."

Although it's not entirely clear how bupropion helps with smoking cessation, it appears to disrupt the brain chemistry underlying nicotine addiction and may also block nicotine receptors, dampening the effects of smoking.

Varenicline provides a constant low level stimulation of the nicotine receptors in the brain and makes cigarettes taste awful so the smoker they can't see the point of taking them as there is no nicotine 'hit'.

EnVivo pharmaceuticals has one drug candidate in clinical trials, EVP-6124, a selective α7 nicotine receptor agonist for Alzheimer's disease and schizophrenia and one follow-up compound, EVP-4473, that has successfully completed pre-clinical development.

It effectively removed the want by blocking the nicotine receptors and I found that the craving for a cigarette lessened until one day, I decided not to buy another pack after I'd smoked the last one in the pack I had.

In studies of cells grown in the laboratory, she and her colleagues have found that cells lining the blood vessels and lungs carry nicotine receptors, molecules on the cell surface that link up with nicotine, which can then disrupt the cells.

Now was the time that Adam wanted to roll back against his chair and draw deeply on a Benson & Hedges Menthol, teasing the smoke down into his lungs, feeling the rush of blood in his head, the yammering of tiny nicotine receptors in his brain as they got their fix.