neutrophil elastase

Neutrophil elastase has been shown to interact with Alpha 2-antiplasmin.

One of the targets addressed in this dossier was neutrophil elastase.

Such aggressive treatment should help slow the assault of neutrophil elastase on the under-protected lungs.

When the body starts an immune response to fight an infection, neutrophils release neutrophil elastase.

The same was true in a mouse model genetically modified to produce human α1-antitrypsin, which inhibits neutrophil elastase.

How do high neutrophil elastase levels increase inflammation and cause weight gain and other metabolic problems?

Primary structure of human neutrophil elastase.

This eventually leads to emphysema from unregulated neutrophil elastase activity in the lung tissue.

Phylogenetic analysis suggested that ecotin has an exogenous target, possibly neutrophil elastase.

The gene encoding neutrophil elastase, ELA2, consists of five exons.

Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis.

The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter.

The imbalance between neutrophil elastase and its inhibitor, α1-antitrypsin, is likely an important contributing factor in the development of obesity, inflammation, and other health problems.

Neutrophil elastase is an important protease enzyme that when expressed aberrantly can cause emphysema or emphysematous changes.

Alpha 1-antitrypsin is a protease inhibitor that provides a protective effect from inflammatory cell proteases, especially neutrophil elastase.

Key words: b-lactams, neutrophil elastase, protease inhibitors, peptides.

Elastin from human aorta was incubated with human neutrophil elastase under conditions favoring proteolysis.

Neutrophil elastase is responsible for the blistering in bullous pemphigoid, a skin condition, in the presence of antibodies.

There appear to be two forms of neutrophil elastase, termed IIa and IIb.

Several lines of evidence support the concept that neutrophil elastase contributes to the pathogenesis of emphysema [ 6, 7].

Several diseases, including those listed, are actually the result of SLPI and α1-antitrypsin defenses being overwhelmed by neutrophil elastase.

However, neutrophils that produce abnormal neutrophil elastase protein appear to have a shorter lifespan than normal neutrophils.

Neutrophil elastase is closely related to other cytotoxic immune serine proteases, such as the granzymes and cathepsin G.

Because of the increased neutrophil elastase burden created during infection in an affected individual's lungs, the Alpha-1 Association strongly recommends prompt, aggressive treatment of infections.

They found that mice completely lacking the neutrophil elastase enzyme don't get as fat as normal mice, even when fed a high-fat diet.