neurosteroids

This is similar to many of the previously known neurosteroids.

The brain requires the use of many neurosteroids to develop and function properly.

It is also the basic building block of steroid hormones, including neurosteroids.

Neurosteroids, including ganaxolone have a broad spectrum of activity in animal models.

However in recent studies, throughout the brain and spinal fluid, vitamin D has begun to surface as one of these neurosteroids.

It is composed of a 3:1 mixture of alfaxalone and alfadolone, two neurosteroids.

Levels of neurosteroids such as allopregnanolone decline in the brain in old age and AD.

Neurosteroids affect synaptic functioning, are neuroprotective, and enhance myelinization.

Several synthetic neurosteroids have been used as sedatives for the purpose of general anaesthesia for carrying out surgical procedures.

Neurosteroids have a wide range of potential clinical applications from sedation to treatment of epilepsy and traumatic brain injury.

Sigma1 (neurosteroids)

The tetrahydroxazole ring that cloxazolam and oxazolam have decreases the inhibitory potency of benzodiazepines on neurosteroids.

Neuroactive steroids (or neurosteroids) rapidly alter neuronal excitability through interaction with neurotransmitter-gated ion channels.

The role of neurosteroids in the anxiolytic, antidepressive- and anticonvulsive effects of selective serotonin reuptake inhibitors.

Allopregnanolone and THDOC are neurosteroids, with the latter having effects on the susceptibility of animals to seizures.

The pharmacological actions of benzodiazepines at the GABAa receptor are similar to those of neurosteroids.

Baulieu discovered that DHEA and pregnenolone are produced in the brain and introduced the term "neurosteroids" in 1981.

However, bretazenil has been found to enhance the effects of neurosteroids acting on the neurosteroid binding site of the GABA receptor.

Many benzodiazepines (diazepam, medazepam, estazolam, temazepam, flunitrazepam and nitrazepam) potently inhibit the enzymes involved in the metabolism of neurosteroids.

Neurosteroids are synthesized in the central and peripheral nervous system, especially in myelinating glial cells, from cholesterol or steroidal precursors imported from peripheral sources.

Certain antidepressant drugs such as fluoxetine and fluvoxamine which are generally thought to act primarily as selective serotonin reuptake inhibitors have also been found to increase the levels of certain neurosteroids.

IV lidocaine or local lidocaine injections, hormone therapy ( hormone levels (anabolic neurogenic )with an endocronlogists )neurosteroids,oxytocin, Ziconotide is sometimes effective but patients should find experienced physicians for treatment.

Based on these studies, it has been proposed that increased levels of neurosteroids induced by fluoxetine or fluvoxamine may significantly contribute to or even be the predominant mechanism of action of these antidepressant drugs.

In addition, certain neurons and glia in the central nervous system (CNS) express the enzymes that are required for the local synthesis of pregnane neurosteroids, either de novo or from peripherally derived sources.

Pregnenolone and its sulfate, like DHEA and its sulfate and progesterone, belong to the group of neurosteroids that are found in high concentrations in certain areas of the brain, and are synthesized there.