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A deficit within muscarinic cholinergic receptors of the eccrine sweat glands.
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors.
Carbachol elicits this REM sleep-like state via activation of postsynaptic muscarinic cholinergic receptors (mAChRs).
Muscarinic cholinergic receptors around sweat glands may be reduced in numbers causing unbound acetylcholine to act on both mast cells and sensory nerve terminals causing urticaria and pain.
Drugs that inhibit the muscarinic cholinergic receptor (anticholinergics) such as atropine and scopolamine are called vagolytic because they inhibit the action of the vagus nerve on the heart, gastrointestinal tract, and other organs.
An analgesic effect, mediated in part by nitric oxide as well, through the upregulation of inducible nitric oxide synthase (iNOS), an increase in endogenous opiates, muscarinic cholinergic receptors and serotonin receptors 5-HT1a and 5-HT3, was repeatedly evidenced.