multifocal osteomyelitis

Chronic recurrent multifocal osteomyelitis and congenital dyserythropoietic anemia (Majeed syndrome)

An entity initially known as Chronic recurrent multifocal osteomyelitis (CRMO) was first described in 1972.

Majeed syndrome is an inherited skin disorder characterized by chronic multifocal osteomyelitis, congenital dyserythropoietic anemia and a neutrophilic dermatosis.

GeneReview/NIH/UW entry on Majeed syndrome (Chronic recurrent multifocal osteomyelitis, chronic dyserythropoietic anemia, and transient inflammatory dermatosis)

The roles played by LPIN2 and the human homolog of pstpip2, PSTPIP2, in the etiology of chronic recurrent multifocal osteomyelitis are uncertain but are currently being investigated."

Other experts found that "mutations in LPIN2 cause a syndromic form of chronic recurrent multifocal osteomyelitis known as Majeed syndrome, while mutations in pstpip2 cause a murine form of the disorder.