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Multifocal fibrosclerosis and idiopathic fibrosclerosis are disorders of unknown aetiology, characterised by fibrous lesions (co-)occurring at a variety of sites.
In view of the familial nature of these findings, members of this dynasty likely suffered from a multi-organ fibrotic condition such as Erdheim-Chester disease or a familial multifocal fibrosclerosis where thyroiditis, obesity and ocular proptosis may have all occurred concurrently.
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