multidrug resistance protein , MRP (Abkürzung)

Multidrug resistance protein 3 is a protein that in humans is encoded by the ABCB4 gene.

Impaired biliary excretion of bilirubin glucuronides is due to a mutation in the canalicular multidrug resistance protein 2 (MRP2).

Small multidrug resistance protein is a family of integral membrane proteins which confer drug resistance to a wide range of toxic compounds by removing them for the cells.

This protein accounts for approximately 70% of such transport in human cell lines, while the remainder appears to be accounted for by Multidrug Resistance Protein 1 (MRP1).

Two multi-spanning digestive vacuole membrane proteins are known: the multidrug resistance protein 1 and Chloroquine Resistance Transporter (CRT).

Subfamily ABCC contains thirteen members and nine of these transporters are referred to as the Multidrug Resistance Proteins (MRPs).

PFIC-3 is caused by a variety of mutations in ABCB4, the gene encoding multidrug resistance protein 3 (MDR3), which codes for a flippase responsible for phosphatidylcholine translocation.

Quoted in Nature News, "Of Cellular Dynamics; A new study says multidrug resistance proteins could explain why yeast cells and cells of other organisms are not able to go on making copies of themselves.

The activation of PI3K in that report was also associated with recruitment of sister of P-glycoprotein (the bile acid export pump) and other multidrug resistance proteins to the canalicular membrane [ 16 ] .

They have also shown efficacy against cells with expression of mutations in the paclitaxel binding site or expression of ABC transporter multidrug resistance protein 7 (MRP7) (which show resistance to epothilone B).

The release of prostaglandin has now also been shown to be mediated by a specific transporter, namely the multidrug resistance protein 4 (MRP4, ABCC4), a member of the ATP-binding cassette transporter superfamily.

Conjugates and their metabolites can be excreted from cells in phase III of their metabolism, with the anionic groups acting as affinity tags for a variety of membrane transporters of the multidrug resistance protein (MRP) family.

Leith CP, Kopecky KJ, Chen IM, et al.: Frequency and clinical significance of the expression of the multidrug resistance proteins MDR1/P-glycoprotein, MRP1, and LRP in acute myeloid leukemia: a Southwest Oncology Group Study.