mossy fibre , auch: mossy fiber AmE

Each granule cell is receiving an input from two different mossy fibre inputs.

The Golgi cell acts by altering the mossy fibre - granule cell synapse.

Mossy fibres make an excitatory connection onto granule cells which cause the granule cell to fire an action potential.

The projection is technically difficult to study, and the locus and cellular mechanisms of mossy fibre LTP remain controversial.

These inhibit the mossy fibre evoked EPSCs of the granule cell in a temperature and frequency dependent manner.

They receive excitatory input from mossy fibres, also synapsing on granule cells, and parallel fibers, which are long granule cell axons.

The main synapse made by these cells is a synapse onto the mossy fibre - granule cell excitatory synapse in a glomerulus.

The glomerulus is made up of the mossy fibre terminal, granule cell dendrites, the Golgi terminal and is enclosed by a glial coat.

Mossy fibres terminate in the stratum lucidum of area CA3, a subfield devoid of NMDA receptors.

Additionally the GABA acts on GABA-B receptors which are located presynaptically on the mossy fibre terminal.

Consistent with this observation, LTP in mossy fibres is not blocked by the NMDA antagonist AP5 (ref. 163); moreover, it appears to be nonassociative.

Different patterns of mossy fibre input will produce unique patterns of activity in granule cells that can be modified by a teaching signal conveyed by the climbing fibre input.

This pause response, called a Purkinje cell CR, was also obtained when direct mossy fibre stimulation was used as the CS and direct climbing fibre stimulation as the US.