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False positive monospot tests may occur in cases of HIV, lymphoma or lupus.
Only half of the patients presenting with the symptoms held by mononucleosis and a positive heterophile antibody test (monospot test) meet the entire set of criteria.
The mononuclear spot test or monospot test, a form of the heterophile antibody test, is a rapid test for infectious mononucleosis due to Epstein-Barr virus (EBV).
Walid MS, Ajjan M, Patel N: Borreliosis And Human Granulocytic Anaplasmosis Coinfection With Positive Rheumatoid Factor And Monospot Test: Case-Report.