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Therefore, the involvement of other modifying genes is very likely.
Environmental factors and additional, modifying genes and are also likely to play major roles.
The intensity of the coat color is under control of a set of modifying genes.
Many coat color modifying genes affect the skin and eyes as well as the coat color.
Maybe the first thing that happens when species diverge is that they start modifying genes - imprinting them - and eventually, as a consequence, they cannot mate.
The steroid/receptor complexes dimerise and interact with cellular DNA in the nucleus, binding to steroid-response elements and modifying gene transcription.
There almost certainly is a group of modifying genes, as well possible environmental factors like diet or medications or other factors that influence the expression of the abnormal genes.
This strongly suggests the presence of modifying genes that affect the phenotypic expression of this mutation, or possibly the interaction of the BRCA2 mutation with environmental factors.
For many years this was believed to be a separate mutation from the mutation we now know as the Clearflight Pied, but by 1961 it was 'almost certain' that these were the same basic mutation, the difference between them being due to the selection of different modifying genes by breeders.