mitotic index

Mitotic index is a measure for the proliferation status of a cell population.

Short S-shaped fascicles, inflammation, accelerated mitotic index with normal mitoses.

The mitotic index is an important prognostic factor predicting both overall survival and response to chemotherapy in most types of cancer.

GISTs of the stomach wall are considered malignant when they exceed 5 to 10 cm, have a high mitotic index, or have metastasized.

Aqueous extracts reduced mitotic index, but induced chromosomal aberrations and mitotic aberrations in comparison with control, significantly.

However, in young pigs and probably in older breeding stock as well, the virus replicates extensively and is found in many tissues and organs with a high mitotic index.

It may lose much of its predictive value for elderly populations, for example a low mitotic index loses any prognostic value for women over 70 years old with breast cancer.

In contrast, in proximal limb mesenchyme there is no difference in mitotic index between FGF-4-treated -AER and +AER limbs (data not shown).

Using an ocular grid (50μmx50μm), the mitotic index was determined by counting the number of mitoses per total number of nuclei within 50μm of the AER or exposed surface.

These findings include higher than expected frequencies of medullary histology, high histologic grade, areas of necrosis, aneuploidy, high S-phase fraction, high mitotic index, and frequent TP53 mutations.

Thickness and/or level of invasion of the melanoma, mitotic index, presence of tumor infiltrating lymphocytes, number of regional lymph nodes involved, and ulceration or bleeding at the primary site affect the prognosis.

While low-grade tumors are usually curable by surgery alone, higher-grade sarcomas (as determined by the mitotic index and by the presence of hemorrhage and necrosis) are associated with higher local treatment failure rates and increased metastatic potential.

The Trojani system scores the sample, depending on tumour differentiation, mitotic index, and tumour necrosis, between 0 and 6 and then converts this into a grade of between 1 and 3, with 1 representing a less aggressive tumour.

Later, the processes slow down with the shift to increased differentiation with a rapid fall in mitotic index in both embryo and fetal membranes after day 14, thus it becomes difficult to obtain chromosome preparations from the later stages, particularly shortly preceding birth.

Figure 1depicts the intense, heterogeneous nuclear staining of glomerular podocytes and tubular epithelium from hyperplastic nephrons in the diseased transgenics versus the absent staining of nephrons in the non-transgenics consistent with the very low mitotic index in normal kidneys of adult animals [ 26 ] .