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While mitosis can occur in the absence of cytokinesis, cytokinesis requires the mitotic apparatus.
And, together with Daniel Mazia, he was the first to isolate the mitotic apparatus and subject it to biochemical study.
It also plays a role in spindle assembly through its interaction with nuclear mitotic apparatus (NuMa), therefore allowing bipolarity.
Brinkley is attempting to uncover the molecular basis of errors and defects in the nucleus and mitotic apparatus that cause aneuploidy.
GPSM2 has been shown to interact with Nuclear mitotic apparatus protein 1 and GNAI2.
Nuclear mitotic apparatus protein 1 is a protein that in humans is encoded by the NUMA1 gene.
Dynactin contributes to mitotic spindle pole focusing through its binding to nuclear mitotic apparatus protein (NuMA).
Because the centromere is the point of attachment for the mitotic apparatus, acentric fragments are not evenly distributed to the daughter cells in cell division (mitosis and meiosis).
The mitotic apparatus is made up of a central spindle and polar asters made up of polymers of tubulin protein called microtubules.
After joining the University of California at Berkeley in 1951, he and a colleague, Katsuma Dan, the Japanese biologist, isolated the mitotic apparatus, a protein-based structure that controls cell division.
Just as higher forms of life have evolved a complex mitotic apparatus to partition duplicated DNA during cell division, bacteria require a specialized apparatus to partition their duplicated DNA.
Wells RA, Catzavelos C, Kamel-Reid S: Fusion of retinoic acid receptor alpha to NuMA, the nuclear mitotic apparatus protein, by a variant translocation in acute promyelocytic leukaemia.
The purpose for in vivo testing is to determine the potential of DNA damage that can affect chromosomal structure or disturb the mitotic apparatus that changes chromosome number; the factors that could influence the genotoxicity are ADME and DNA repair.
Research work during the last 30 years established such important phenomena as stable mRNA and translational control, isolation and characterization of the mitotic apparatus, and the realization that the major structural proteins of the mitotic apparatus are microtubules.