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In general the antimicrobial activity of these peptides is determined by measuring the minimal inhibitory concentration (MIC), which is the lowest concentration of drug that inhibits bacterial growth.
CRE can be difficult to detect because some strains that harbor blakpc have minimal inhibitory concentrations (MICs) that are elevated but still within the susceptible range for carbapenems.
At or below the minimal inhibitory concentration (MIC), filamentation occurred mainly at these concentration and bacteria remained as viable within the vacuoles of immortalized human macrophages, not rapidly killed.
Susceptibility thresholds for clarithromycin are minimal inhibitory concentrations of 32 g/mL and a minimal inhibitory concentration of 256 g/mL for azithromycin (207).
Heifets L, Lindholm LP, Libonati J. Radiometric broth macrodilution method for determination of minimal inhibitory concentrations (MIC) with Mycobacterium avium complex isolates: proposed guidelines.
The minimal inhibitory concentration of H. capsulatum is 0.01 g/mL, and although minimally effective serum concentrations have not been determined, a serum concentration of 1.0 g/mL is recommended; dosage should be reduced if concentrations exceed 10 g/mL (382).
According to a 2012 study done at Northwestern Memorial Hospital in Chicago, Il, carbapenem minimal inhibitory concentrations (MICs) results may be more predictive of clinical patient outcomes than the current categorical classification of the MIC being listed as susceptible, intermediate, or resistant.