The social and cognitive impairments seen in patients suffering from pervasive developmental disorders can be attributed due to mind blindness.

Patients that experienced frontal lobe injuries due to severe head trauma showed signs of mind blindness, as a result of a lost ToM.

The name of this condition dates back to the case study work of Jean-Martin Charcot and Hermann Wilbrand, and was first described by Otto Potzl as "mind blindness with disturbance of optic imagination".

Mind-blindness is a state where the ToM has not been developed or lost in an individual.

An alternative approach to the social impairment observed in mind-blindness focuses on emotion of subjects.

Some studies have shown that the orbitofrontal cortex is not directly associated with the theory of the mind or mind-blindness.

Disruption of this neural network leads to mind-blindness in schizophrenic individuals.

Mind-blindness can be described as a cognitive disorder where an individual is unable to attribute mental states to the self and other.

People with schizophrenia also show deficits associated with mind-blindness.

They could even understand that because of that mind-blindness, human society had different imperatives from those of their own.

Another clue towards a possible explanation of mind-blindness in autism was done by Castelli and colleagues.

A study by Bowler concluded that mind-blindness and social impairment is not as straightforward as previously thought.

Conversely the absence or impairment of the ToM that leads to mind-blindness does not lead to social impairments.

These are considered important regions for the activation of the ToM regions and are associated with the mind-blindness.

However it is still debated whether the inactivation of the medial frontal lobe is involved in mind-blindness.

The delay facilitates mind-blindness.

Brain lesion studies show that there are differences seen in the laterality of brain that account for mind-blindness.

Mind-blindness is associated with autism and Asperger's syndrome (AS) patients who tend to show deficits in social insight.

Mind-blindness is usually associated with patients with pervasive developmental disorders such as autism and Asperger's Syndrome.

Many have also pointed out that Mind-blindness wrongly categorizes autism as a problem to be fixed, rather than a condition to be accommodated.

Prof Baron-Cohen defines autism as a kind of mind-blindness in which the brain cannot deal with unexpected changes – and human behaviour can be very unpredictable.

In patients suffering from semantic dementia, the temporal regions of these patients undergo atrophy and lead to certain deficits which can cause mind-blindness.

The cells of the ACC develops at the age of 4 months suggesting that the manifestations of mind-blindness may occur around this time.

It is suspected that the damage to the orbitofrontal cortex brings upon subtle impairments, but not a total loss of the ToM that would to mind-blindness.

However there is an ongoing debate as to whether individuals with schizophrenia have an impaired ToM leading to mind-blindness or display an exaggerated ToM.

There is some evidence that suggests that certain patients develop a rudimentary ToM and do not suffer from complete lack of ToM causing mind-blindness.

Furthermore Frith has predicted that the extent of mind-blindness depends on whether the objective/behavioural or subjective symptoms of ToM abilities prevail.

The cognitive impairment linked to mind-blindness is best explained by a modular theory; the domain specific capabilities that account for mindreading and mentalization are lost in schizophrenia.