microsatellite instability , MSI (Abkürzung)

The microsatellite instability in hereditary nonpolyposis colon cancer most commonly affects such regions.

Approximately 70% of tumors associated with the MTS have microsatellite instability.

This leads to microsatellite instability which can eventually lead to malignant transformation in polyps on the right side of the colon.

In colorectal cancer, they are associated with microsatellite instability cancers, as may be seen in Lynch syndrome.

If there is microsatellite instability identified, there is a higher likelihood for a Lynch syndrome diagnosis.

Frameshift mutations are known to be a factor in colorectal cancer as well as other cancers with microsatellite instability.

In laboratory culture studies, quercetin increased the sensitivity of resistant colorectal tumors with microsatellite instability to the chemotherapy drug, 5-fluorouracil.

Microsatellite instability (MSI) which tend to have diploid karyotypes.

The ACVR2 gene is often found inactivated in prostate cancer and tumors with microsatellite instability.

Microsatellite instability is detected by PCR based assays that reveal these novel microsatellites.

These microsatellite instability results were confirmed in at least two independent experiments and correspond to previous published results for this marker [ 2].

Prostate cancers due to MMR gene mutations have been shown to have evidence of microsatellite instability.

Microsatellite stability (redirected to Microsatellite instability)

Methylation status was correlated with clinical and histologic characteristics, and microsatellite instability (MSI).

Characteristics that we examined included: histology, stage, tumor size, patient's age, clinical outcome, treatment response, HPV type, and microsatellite instability.

Microsatellite instability and LOH distinguish multiple pathways of progression in the remaining two tumors (cases 2 and 27).

Another form of instability is microsatellite instability Microsatellite sequences may show alterations in one or both alleles in some tumors.

Both the Msh6 and Msh2 mutant mice develop gastrointestinal cancer but the tumours differ in their microsatellite instability (MI) status.

Our statistical correlative analysis of promoter methylation with clinicopathologic parameters, HPV type, and microsatellite instability identified significant associations.

Mutations in the human homologues of the Mut proteins affect genomic stability, which can result in microsatellite instability (MI).

Microsatellite instability detects that MMR is functionally impaired, but does not imply the mechanism by which it is impaired.

These short repetitive sequences of DNA become unstable, leading to a state of microsatellite instability (MSI).

The presence of multiple replication errors or microsatellite instability within tumours is actually associated with increased survival., Future studies in this area will help to elucidate these relationships more precisely.

Rigau V, Sebbagh N, Olschwang S, et al.: Microsatellite instability in colorectal carcinoma.

Because of the nature of the mutations that this complex repairs, this is probably the state of MSH2 that causes the microsatellite instability phenotype.