microgyria

This demonstrates an equivalent microgyria size in all environmental groups.

Study 3 assessed the effects of P1 induced microgyria in males and females.

Study 1 assessed environmental variations on the effects of the P1 induced microgyria in male subjects.

Study 2 assessed the effects of P1 induced microgyria in male rats across three stages of development.

The extent of brain-wide changes induced by the relatively restricted freezing lesion that produces microgyria is, however, unknown.

Further, reorganization (i.e., brain weight and volume reduction due to microgyria) was evident by P30 and remained consistent into adulthood.

It has been shown that these malformations, resembling human microgyria, are associated with widespread disturbances in neuronal organization [ 4 5 ] .

Rapid auditory processing deficits have been found in males with induced microgyria using both an operant condition paradigm and a reflex modification paradigm [ 15 19 20 21 ] .

Micropolygyria also known as polygyria or microgyria is a Neuronal migration disorder, a developmental anomaly of the brain characterized by development of numerous small convolutions (microgyri), causing mental retardation.

Further, animals with induced microgyria showed poorer performance in discrimination learning and took longer paths to the target in the Morris Water Maze than sham littermates [ 22 ] .

Analysis of histologic brain and neocortical volume confirmed the effects of lesion on brain weight, and suggest that the reduction in volume associated with microgyria is proportionally greater in the cerebral cortex.

Albert Galaburda of Harvard Medical School noticed that language centers in dyslexic brains showed microscopic flaws known as ectopias and microgyria (Galaburda et al., 2006, Nature Neuroscience 9(10): 1213-1217).

Here we present evidence that induced bilateral focal microgyria leads to significant reductions in overall brain weight that are quite robust, being seen at all ages measured (P30 - P118), in both males and females, and are unaffected by acoustic rearing experiences.