metabolism of xenobiotics

This enzyme participates in metabolism of xenobiotics by cytochrome p450.

CYP2D6 accounts for only a small percentage of total hepatic CYP450s but it is one of the main pathways for phase one metabolism of xenobiotics.

Cytochrome P2C8 (abbreviated CYP2C8), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body.

CYP2C9 and CPY3A4 are members of the cytochrome P mixed-function oxidase system, and as such are enzymes involved in the metabolism of xenobiotics in the body.

The main cytochromes P450 participating in the metabolism of xenobiotics are families 1, 2, and 3, which are promarily located within the liver, although specific forms of cytochrome P450 are expressed in particular extrahepatic tissues.

This enzyme participates in 7 metabolic pathways: fatty acid metabolism, androgen and estrogen metabolism, gamma-hexachlorocyclohexane degradation, tryptophan metabolism, arachidonic acid metabolism, linoleic acid metabolism, and metabolism of xenobiotics by cytochrome p450.

Hepatic enzymes are responsible for the metabolism of xenobiotics by first activating them (oxidation, reduction, hydrolysis and/or hydration of the xenobiotic), and then conjugating the active secondary metabolite with glucuronic or sulphuric acid, or glutathione, followed by excretion in bile or urine.