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The metabolic block occurs in the conversion of glycine into smaller molecules.
Metabolic blocks can occur for a variety of reasons:
Administration of uridine, which is converted to UMP, will bypass the metabolic block and provide the body with a source of pyrimidine.
Such wide-reaching results are remarkably reminiscent of the drug pictures of many of the homoeopathic remedies, which are visualized as being the keys which can unlock various metabolic blocks.
Since there are many hundreds, if not thousands, of enzymes in the body, the number of potential metabolic blocks is indeed large - large enough to accommodate all the remedies of the homoeopathic materia medica.
The treatment, in the case of phenylketonuria, is to put the baby on to a phenylalanine-free diet, thus bypassing the metabolic block, and this is why it is important to diagnose the condition as soon after birth as possible.