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This normal process stimulates mesangial cell proliferation and matrix deposition.
Mesangial cells are specialized cells around blood vessels in the kidneys, at the mesangium.
Mesangial cells are modified smooth muscle cells that lie between the capillaries.
There are three primary functions of intraglomerular mesangial cells: filtration, structural support, and phagocytosis.
The initiation of contraction of mesangial cells is similar to that of smooth muscle.
Additionally, mesangial cells are able to monitor glucose levels via processes sent into the capillary lumen.
Carnosine was found to inhibit diabetic nephropathy by protecting the podocytes and mesangial cells.
In addition, the glomeruli of the kidneys contain smooth muscle-like cells called mesangial cells.
Mesangial cells also phagocytize glomerular basal lamina components and immunoglobulins.
Pericytes and renal mesangial cells are some examples of modified myofibroblast like cells.
Intraglomerular mesangial cells are found in the interstitium between endothelial cells of the glomerulus.
Intraglomerular mesangial cells provide structural support for and regulate blood flow of the glomerular capillaries by their contractile activity.
Mesangial cells in the renal glomerulus use endocytosis to take up and degrade circulating immunoglobulin.
Mesangial cells were not examined since Stx-1 has not been demonstrated to affect their viability [ 13 ] .
It contains three components: the macula densa, juxtaglomerular cells, and extraglomerular mesangial cells.
Mesangial cells are of monocyte or smooth muscle origin, typically covering 30% of glomerular capillaries.
Intraglomerular mesangial cells are specialized pericytes located among the glomerular capillaries within a renal corpuscle of a kidney.
Mesangial cells also have phagocytic activity, removing proteins and other molecules trapped in the glomerular basement membrane or filtration barrier.
Microscopic examination of biopsy specimens shows increased number of mesangial cells with increased matrix (the 'cement' that holds everything together).
The glomerular membrane consists of mesangial cells, modified pericytes that in other parts of the body separate capillaries from each other.
Adenosine may then bind to adenosine A receptors on extraglomerular mesangial cells, triggering a rise in intracellular calcium levels.
Cross linking antibody induced aggregation of Thy1 cause death of thymocytes and mesangial cells mainly by apoptosis despite Bcl2 upregulation.
Renal mesangial cells exposed to high glucose media release cMVs containing tissue factor, having a angiogenic affect on endothelial cells.
Intraglomerular mesangial cells are also major contributors to the extracellular matrix which contains fibronectin, type IV collagen, perlecan, and laminin.
This term is often used interchangeably with mesangial cell, but in this context refers specifically to the intraglomerular mesangial cells.