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In the knockout mice, meiotic chromosome synapsis is defective.
Mammalian meiotic chromosome preparation has progressed considerably since the early days when a good squash preparation was the best that could be achieved.
These data provide additional evidence that two meiotic divisions had occurred and that the diploids arose as a consequence of meiotic chromosome segregation defects.
The appearance of the pairing events in the SC reflect exactly the pairing behaviour of the meiotic chromosomes throughout prophase.
This heterogeneous phenotype is characteristic of a variety of mutations that directly affect meiotic chromosome dynamics [ 37 38 39 ] .
"Physical mapping of DNA repetitive sequences to mitotic and meiotic chromosomes of Brassica oleracea var.
Ray-Chaudhuri, R. (1967) Mitotic and meiotic chromosomes of the koel Eudynamys scolopacea scolopacea.
We also employed a combination of cytological and genetic approaches to reveal the nature of meiotic chromosome segregation defects for each chromosome in each of the three mutants.
To define more precisely the requirement for Rec12 in meiotic chromosome dynamics, we used gene replacement to generate a null ( rec12-D15 ) mutation and a mutation in the putative active site tyrosine ( rec12-Y98F ).
This reinforces the view that there may be functional differences in arm and pericentric cohesion and perhaps different mechanisms to load cohesin, as has been proposed for cohesin on meiotic chromosomes for S. pombe [18].
This phenomenon, sometimes referred to as a 'synizetic knot', and contrasted with the chromosome 'bouquet' more typically observed, is characterized by the localization of the meiotic chromosomes in a tight clump on one side of the nucleus.
Mod(mdg4) isoform C, the modifier of the mdg4 locus in Drosophila melanogaster (Fruit fly), where mdg4 encodes chromatin proteins which are involved in position effect variegation, establishment of chromatin boundaries, nerve path finding, meiotic chromosome pairing and apoptosis.