"We felt it was important to use the maximal dose, based on laboratory studies," Dr. Salmon said.
The treatment recommendation is to start treatment with a half of maximal recommended dose for at least two months.
If the patient was completely non-responsive to the maximal recommended dose of sertraline (200 mg), further increasing the dose did not significantly improve the response rates.
Compared with other medications of the thiazide class, chlortalidone has the longest duration of action but a similar diuretic effect at maximal therapeutic doses.
It has been shown to decrease angina episodes in individuals with coronary artery disease on maximal doses of amlodipine.
Such control permits a spider to administer either a dry bite, a dose appropriate to the nature of the prey or enemy, or a maximal dose.
They found a maximal dose of resveratrol increased the median lifespan by 56%.
This leads to the sense that "nothing works" when, in fact, nothing has been tried to its maximal therapeutic dose.
Therefore 10 10iu was the maximal accepted dose for these experiments.
The other indication for insulin is of course when glycaemic control is poor on a maximal dose of a sulphonylurea.