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It can also be confused with lymph nodules, considering the similarity in shape and size.
Antigens stimulate T and B lymphocytes in the lymph nodule cortex.
Reticular cells are found in many tissues including the spleen, lymph nodes and lymph nodules.
In the cortex, lymphoid tissue is organized into lymph nodules, where T lymphocytes fill the reticular network called the T cell zone and B lymphocytes are accumulated in an area called the B cell follicle.