liver lobule

They arise from the substance of the liver, more specifically the central vein of the liver lobule.

They are found between the bile canaliculi and interlobular bile ducts near the outer edge of a classic liver lobule.

Hepatic Histology: The Lobule - Describes the liver lobule and central vein.

This is the most common type of drug-induced liver cell necrosis where the injury is largely confined to a particular zone of the liver lobule.

In the adult liver, hepatocytes are not equivalent, with position along the portocentrovenular axis within a liver lobule dictating expression of metabolic genes involved in drug metabolism, carbohydrate metabolism, ammonia detoxification, and bile production and secretion.