liposoluble

Drugs that penetrate the blood-brain barrier naturally are distinguished by being liposoluble, which means they dissolve in fats or oil rather than in water.

Mezerein is higly liposoluble and can cause vomiting, diarrhea and burning of the mouth.

Pharmatec Inc. of Alachua, Fla., is working with several pharmaceutical companies on creating liposoluble versions of drugs.

For example, a liposoluble drug will tend to accumulate in body fat and water-soluble drugs will tend to accumulate in extracellular fluids.