linkage disequilibrium

Linkage disequilibrium is necessary to detect association; however, it is not sufficient.

White maize lines had increased diversity and no evidence of linkage disequilibrium associated with a selective sweep.

If at some time we observe linkage disequilibrium, it will disappear in the future due to recombination.

Lewontin later introduced the D' measure of linkage disequilibrium.

Firstly, African populations exhibit greater genetic diversity and less linkage disequilibrium because of their long history.

This fact complicated efforts to map the gene via linkage disequilibrium [ 60].

"The extent of linkage disequilibrium in Arabidopsis thaliana".

Under these parameters a linkage disequilibrium of more than 50% means there is a possible link to the gene allele and inheritance.

These studies roughly plot to the expected fixation distribution of alleles, given linkage disequilibrium between adjacent sites.

Hence linkage disequilibrium may build up, and may substantially affect the equilibrium mutational load.

Genetic studies can use this admixture linkage disequilibrium to search for disease alleles with fewer markers than would be needed otherwise.

The analysis process consisted of plotting extensive linkage disequilibrium of ancestral and current alleles.

This may represent linkage disequilibrium.

Linkage disequilibrium calculations Pairwise linkage disequilibria were calculated using the r 2statistic.

The basic idea is that linkage disequilibrium can easily occur (for many reasons) between two (or more) polymorphic sites that are under selection.

One method is to measure linkage disequilibrium, i.e., whether a given haplotype is overrepresented in the population.

The amount of linkage disequilibrium depends on the difference between observed allelic frequencies and those expected from a homogenous, randomly distributed model.

Furthermore, they report values for D ' that are constant across a haplotype block, while we find variability in linkage disequilibrium, even over short distances.

When this occurs, an allele that raises the recombination rate (and decreases the linkage disequilibrium) can cause selection to act more efficiently.

It is this linkage disequilibrium that enables scientists to map the locations of mutations that cause heritable genetic diseases.

Therefore, the presence of strong linkage disequilibrium might indicate that there has been a recent selective sweep, and can be used to identify sites recently under selection.

Thus, A1::DQ2 haplotype is both long and shows greater deficiency of recombination (called linkage disequilibrium).

It could be associated with particular DLA alleles/haplotypes or caused by the strong linkage disequilibrium.

The genetics of this situation cannot be clarified in the absence of a detailed breeding program, but two loci with linkage disequilibrium is a possibility.

This tendency is measured by finding how often two alleles occur together on a single chromosome compared to expectations, which is called their linkage disequilibrium.