knudson hypothesis

Field cancerisation may be an extended form of the Knudson hypothesis.

In tumor cells copy-neutral LOH can be biologically equivalent to the second hit in the Knudson hypothesis.

For example, a mutation limited to one oncogene would be suppressed by normal mitosis control and tumor suppressor genes, first hypothesised by the Knudson hypothesis.

Among his many contributions to the field was the formulation of the Knudson hypothesis in 1971, which explains the effects of mutation on carcinogenesis (the development of cancer).

The Knudson hypothesis (aka multiple-hit hypothesis) is the hypothesis that cancer is the result of accumulated mutations to a cell's DNA.

The two hit hypothesis (aka Knudson hypothesis ) is often used to explain the manifestation of polycystic kidney disease later in life even though the mutation is present at birth.

In 1953, in a paper published in the British Journal of Cancer, he first proposed the multi-mutation theory on cancer, today generally known as Knudson hypothesis after Alfred G. Knudson's work from 1971.