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Keratolytic agents (chemicals to remove keratin) such as podophyllin are successful, but carry safety concerns.
It combines sodium sulfacetamide, a sulfonamide antibiotic, and sulfur, a keratolytic agent.
Also, benzoyl peroxide dries out the area, preventing clogged pores and is a keratolytic agent.
Absorption is greater in an ointment base, in the presence of a keratolytic agent such as salicylic acid and under occlusion.
Topical resorcinol is a keratolytic agent that targets the follicular keratin plug and has been shown to have efficacy in several case series studies.
Essentially, keratolytic agents such as salicylic acid and sulphur loosen the attachments between the corneocytes and allow them to get swiped off.
Keratolytic agents such as Ammonium lactate (Lac-Hydrin) are used to facilitate the release of retained corneocytes.
The Naturals line of products contains the active ingredient salicylic acid in addition to 8 moisturizers & botanicals plus vitamins B5 & E. Salicylic acid is a keratolytic agent that assists with cell shedding or flaking.
They may also be dissolved with keratolytic agents containing salicylic acid, sanded down with a pumice stone or filed down with a callus shaver, or pared down by a professional such as a podiatrist or a foot health practitioner.