isatin , auch: isatine

Indigo can be converted to isatin and then to oxindole.

He also worked on the synthesis of isatin.

Schiff bases of isatin are investigated for their pharmaceutical properties.

Notably, it is used to synthesize isatin.

This effect has been attributed to various compounds present in the fruits, such as dietary fiber, sorbitol, and isatin.

Prunes and their "juice" contain the natural laxative dihydrophenylisatin (related to isatin).

The reaction of isatin with a base such as potassium hydroxide hydrolyses the amide bond to give the keto-acid 2.

It was observed that isatin forms a blue dye if it is mixed with sulfuric acid and crude benzene.

For example, the alternate synthesis of sunitinib from US patent 6573293 begins by mixing 5-fluoro isatin slowly into hydrazine hydrate.

Synthesis of isatin via a process known as the Claisen isatin synthesis, described for the first time in 1879.

Another classic reaction, the Sandmeyer diphenylurea isatin synthesis (Sandmeyer 1903), starts from diphenylthiourea, potassium cyanide, and lead carbonate.

This reaction is called the Sandmeyer isonitrosoacetanilide Isatin Synthesis and was discovered by Traugott Sandmeyer in 1919:

The Pfitzinger reaction (also known as the Pfitzinger-Borsche reaction) is the chemical reaction of isatin with base and a carbonyl compound to yield substituted quinoline-4-carboxylic acids.

Condensation with acenaphthoquinone gives 8, a dye of the so-called Ciba-Scarlet type, while condensation of 7 with isatin results in the thio-Indigo dye 9.

The syntheses are named in his honor Sandmeyer isonitrosoacetanilide isatin synthesis(1919) and Sandmeyer diphenylurea isatin synthesis(1903)

Recently, Atul Kumar has developed an efficient and green method for the synthesis of tryptanthrin, a biologically active natural product, employing β-cyclodextrin as a catalyst in aqueous media at room temperature from isatoic anhydride and isatin in excellent yields.