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The purification process is usually performed in several steps with "mixed bed ion-exchange columns" at the end of the technological chain.
An ion-exchange process was developed by the Asahi Chemical Company in Japan which applies similar chemistry but effects separation on a proprietary resin ion-exchange column.
B. O. Schütz, S. Specht, and H. J. Born Title Choice of operation parameters of ion-exchange columns for separations of highly radioactive nuclides, Reactor meeting, 10 April 1973, Karlsruhe, Germany.
To do this chemistry, the F is separated from the aqueous solvent by trapping it on an ion-exchange column, and eluted with an acetonitrile solution of 2,2,2-cryptand and potassium carbonate, which gives [(crypt-222)K] F (2) when dried.