intratumoral

Side effects following intratumoral injection are limited to flu-like symptoms and resolve within 24 hours.

This procedure is also called intratumoral ethanol injection.

The intratumoral hypoxia and acidosis may extend to the surrounding tissue.

Harsh has been credited with the creation of a device that assists in aggressive intratumoral radiation.

Spontaneous intratumoral hemorrhage has also been observed.

Intratumoral injection of alcohol.

These observations were corroborated by the results of the intratumoral injection of the β-Galactosidase encoding adenovirus.

Examination of multiple lesions from individual tumors, for example, reveals the presence of intratumoral heterogeneity [ 11, 12, 13].

Intratumoral injection of strain Italien was associated with complete tumor regression in 100% of mice bearing human melanoma tumors.

Intratumoral injections of replication-competent oncolytic viruses of unresectable lesions are being tested in national clinical trials.

Systemic GM-CSF was detected up to 7 weeks following both intratumoral and intravenous injection of JX-594.

Dense infiltration of with CD4 and CD8 T lymphocytes into the tumor was observed following intratumoral injection of JX-594.

Takahashi H, Nakazawa S, Shimura T: Evaluation of postoperative intratumoral injection of bleomycin for craniopharyngioma in children.

The results of imaging studies (computerized tomography scans and magnetic resonance imaging [MRI] scans) are often diagnostic for craniopharyngiomas, with most demonstrating intratumoral calcifications.

Tremmel SC, Götte K, Popp S, et al.: Intratumoral genomic heterogeneity in advanced head and neck cancer detected by comparative genomic hybridization.

In stromal fibroblasts, PDGFRα activation leads to local tissue invasion, production and secretion of VEGF, and elevated intratumoral interstitial pressure.

In its report, the National Cancer Institute also identified a "study of intratumoral injection of delta-9-THC in patients with recurrent glioblastoma" that showed tumor reduction in the test participants.

In another study, intratumoral injections of mistletoe extract (ABNOBAviscum Fraxini-2) demonstrated more antitumor activity than intravenous gemcitabine when injected into mouse xenografts of human pancreatic cancer.

Sigurdson et al showed that when an agent was infused via the hepatic artery, it attained ten times higher intratumoral concentration as compared to when it was given through the portal vein.

Another study of intratumoral injection used the V4UPM strain of NDV in a nude mouse model of tumors produced by subcutaneous injection of human glioblastoma multiform cells.

Ierardi DF, Fernandes MJ, Silva IR, et al.: Apoptosis in alpha interferon (IFN-alpha) intratumoral chemotherapy for cystic craniopharyngiomas.

Conclusions The observations in this study raise the intriguing possibility that selection of head and neck cancer patients for concurrent chemotherapy can be based upon the intratumoral mutational status of M6P/IGF2R .

Beuth J, Ko HL, Schneider H, et al.: Intratumoral application of standardized mistletoe extracts down regulates tumor weight via decreased cell proliferation, increased apoptosis and necrosis in a murine model.

Although intratumoral hemorrhage can occur in any primary or metastatic brain tumor, certain tumors have a greater tendency to bleed, including metastasis from melanoma, choriocarcinoma, and thyroid cancer and the primary brain tumors glioblastoma and oligodendroglioma.

In immune competent mice, intratumoral injection of SLC/CCL21 led to a significant increase in CD4 and CD8 T lymphocytes as well as DC infiltrating the tumor and the draining lymph nodes.