intracellular receptor

Dissociation from the intracellular receptor domains allows them to become active.

Some intracrine peptide hormones also have intracellular receptors.

Background Glucocorticoids influence a wide spectrum of cellular functions through their action on soluble intracellular receptors.

Certain intracellular receptors of the immune system are examples of cytoplasmic receptors.

Intracellular receptors are receptors located inside the cell rather than on its cell membrane.

Cellular responsiveness is restored after dephosphorylation of intracellular receptors and subsequent recycling to the cell surface.

The intracellular receptors are controlled by small molecules, making them suitable targets for small molecule drugs that mimic their natural models.

Some protein hormones also interact with intracellular receptors located in the cytoplasm or nucleus by an intracrine mechanism.

Receptors can be roughly divided into two major classes: intracellular receptors and extracellular receptors.

Small and fatty, these molecules pass naturally through cell membranes and bind with the intracellular receptors to form a ligand-receptor complex.

Their effect is due to their ability to bind to intracellular receptors, modulating the gene expression, and subsequently regulating protein synthesis.

Soluble guanylate cyclase (sGC) is the intracellular receptor for NO.

This mechanistic model raises the possibility that COI1 serves as an intracellular receptor for JA signals.

Intracellular receptors, such as nuclear receptors and cytoplasmic receptors, are soluble proteins localized within their respective areas.

When a test molecule binds with an intracellular receptor and then prompts the DNA, sensitive instruments can then measure the amount of light produced.

Some family members are also believed to transport lipophilic molecules from outer cell membrane to certain intracellular receptors such as PPAR.

The ability to bind to an intracellular receptor, oxysterol binding protein, may be responsible for their inhibition of cholesterol biosynthesis [ 48 49 ] .

The PPARs are a class of intracellular receptors that modulate carbohydrate and fat metabolism and adipose tissue differentiation.

In intracrine signaling, once inside the cell, a signaling molecule can bind to intracellular receptors, other elements, or stimulate enzyme activity (e.g. gasses).

Intracellular receptors include nuclear receptors and cytoplasmic receptors, and are soluble proteins localized within the nucleoplasm or the cytoplasm, respectively.

They are generally intracellular receptors (typically cytoplasmic) and initiate signal transduction for steroid hormones which lead to changes in gene expression over a time period of hours to days.

Rapamycin is a bacterial product that can inhibit mTOR by associating with its intracellular receptor FKBP12.

BECAUSE the different intracellular receptors are similar in shape, drugs like tamoxifen and Retin-A activate more than one at a time, prompting undesirable side effects.

Upon receptor activation, the intracellular receptor domain activates the GTPase, which in turn activates other molecules of the signal transduction chain, either via the α unit or the βγ complex.