intra-arterial injection

Inadvertent intra-arterial injection can also result in endarteritis and thrombosis, with ultimately similar consequences.

Intra-arterial injection (especially in drug addicts)

These findings contrast with those of Beubler et al who used close intra-arterial injections of 5HT.

It has likewise been recommended for treatment of inadvertent intra-arterial injections (10 ml of 1% procaine), as it helps relieve pain and vascular spasm.

Instead, in 1996, it requested from Wyeth the labeling then in use and, without addressing Wyeth's 1988 submission, instructed it to "retain verbiage in [the] current label" regarding intra-arterial injection.

After a few further changes to the labeling not related to intra-arterial injection, the FDA approved Wyeth's 1981 application in 1998, instructing that Phenergan's final printed label "must be identical" to the approved package insert.

In one early study using recombinant protein, a single intra-arterial injection of 500-1000 μg VEGF165 into rabbits with severe experimental hind limb ischemia increased collateral vessels, as detected by angiography and histological analysis [ 6].

Since many injectable drugs used in intensive care and anesthesia, such as sodium pentothal, may lead to serious tissue damage and even amputation if given in an artery the arterial line must be clearly marked to avoid accidental intra-arterial injection of intravenous drugs.

Therefore targeting of the IL-10 gene to the inflamed colon should ideally exploit tissue (i.e. gut) specific promoters to control selective organ gene transfer technology, endothelial specific promoters and also organ specific intra-arterial injection of vector to activate some genes in specific locations [ 57 ] .